Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in 1 Pancreatic Cancer
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چکیده
Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in 1 Pancreatic Cancer 2 Sheema Khan, Mara C. Ebeling, Neeraj Chauhan, Paul A. Thompson, Rishi K. Gara, Aditya 3 Ganju, Murali M. Yallapu, Stephen W. Behrman, Haotian Zhao, Nadeem Zafar, Man Mohan 4 Singh, Meena Jaggi, Subhash C. Chauhan 5 Department of Pharmaceutical Sciences and Center for Cancer Research, University of 6 Tennessee Health Science Center, Memphis, Tennessee, USA. 7 Cancer Biology and Sanford Children’s Health Research Center, Sanford Research, Sioux Falls, 8 South Dakota, USA. 9 Methodology and Data Analysis Center, Sanford Research, Sioux Falls, South Dakota, USA. 10 Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, 11 USA. 12 Department of Pathology, University of Tennessee at Memphis, Memphis, Tennessee, USA. 13 Saraswati Dental College, Lucknow, Uttar Pradesh, India 14 Running title 15 Ormeloxifene suppresses desmoplasia in pancreatic cancer 16
منابع مشابه
Ormeloxifene suppresses desmoplasia and enhances sensitivity of gemcitabine in pancreatic cancer.
The management of pancreatic ductal adenocarcinoma (PDAC) is extremely poor due to lack of an efficient therapy and development of chemoresistance to the current standard therapy, gemcitabine. Recent studies implicate the intimate reciprocal interactions between epithelia and underlying stroma due to paracrine Sonic hedgehog (SHH) signaling in producing desmoplasia and chemoresistance in PDAC. ...
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